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Other side effects include signs of being in heat, including vaginal discharge or spotting, infection of the uterus in intact female dogs (pyometra), cystic endometrial hyperplasia and other abnormalities of the reproductive system, diarrhea, vomiting, lack of energy,。

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DES has been used to treat estrogen responsive tumors, hyperplasia of the prostate gland and in perianal gland adenomas. However, neutering (castration) is the initial。

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